Senior Data Scientist, Biological Discovery

Job Description

• Calico is seeking a Senior Data Scientist to join an agile and interdisciplinary team focused on generating tractable biological insights through innovative and integrative analyses of large scale ‘omics datasets. • Collaborate with scientists throughout R&D to answer key biological questions via creative analysis of high-dimensional datasets and design of high impact experiments • Manifest interdisciplinary research by maintaining a presence across diverse programs at Calico and developing methods to integrate different data modalities • Work effectively as part of an agile and tight-knit analysis team tackling diverse biological questions • Communicate clearly and effectively in verbal, visual, and written form to stakeholders with varying levels of technical knowledge

Qualifications

• Ph.D. / MS and four years of work experience in a quantitative field such as Computer Science, Bioinformatics, Computational Biology, Statistics, Biological Sciences, Genomics, or equivalent preparation • Experience analyzing high-dimensional biological datasets such as bulk RNA-Seq, Ribo-Seq, bulk ATAC-Seq/ChIP-Seq, metabolomics, lipidomics, proteomics, microscopy, and/or cell painting • Experience conducting systems biological analyses that integrate ‘omics datasets, molecular pathways, and genetic data to generate specific testable hypotheses • Fundamental understanding of statistics and biology • Fluency applying R (tidyverse) and/or Python (pandas, numpy, jupyter) to diverse analytical problems • Track record of effective interdisciplinary collaboration and a team-first mentality • Must be willing to work onsite currently at least three days a week • Nice to Haves: • Experience analyzing single cell datasets (e.g., scRNA-Seq, scATAC-Seq) • Experience with CRISPR-based technology (e.g., CROP-Seq, STING-Seq) • Experience in human genetics including analysis and interpretation of rare and common variation

Benefits

• Estimated base salary range for this role is $164,000 - $172,000 • Eligible for two annual cash bonuses